- "Be brave, darling."
- —Susan, comforting Jodie
Susan Holmes was born on September 28, 1964.
At some point of her life, Susan married a man named Philip Holmes, and nine months later, she gave birth their first and only son, born in 1990.
However, the newborn contracted an unknown illness, so, Susan and her husband decided to take their son to the hospital, but despite The doctor's efforts, the newborn died, leaving Susan devastated, after their son's death, the couple adopted a newborn girl named Jodie.
Susan Holmes is Jodie Holmes's adoptive mother, she, in contrast to her husband, genuinely cares for her adoptive daughter, despite Aiden. She adamantly defends Jodie when Philip insists on abandoning her, and instead focuses on trying to help her, as opposed to the easy road of just leaving her.
When leaving Jodie at the DPA, in the care of Nathan Dawkins and Cole Freeman, she is reluctant to leave, taking the time to embrace her. She only leaves at the insistence of Philip, who is more than anxious to have Jodie off his hands. When the player controls Aiden during the Alone chapter and decides to strangle Philip as he leaves the room, when stopped Philip will call the little girl a "monster" and "evil". As he leaves Susan turns to look at Jodie with dawning fear on her face before saying "Oh my god" and leaving.
- In Susan and Philip's bedroom there is a box with a photograph that Jodie can find; the photograph contains a flashback which reveals that Susan and her husband have lost one a newborn son, the loss of a son, can prove why Susan was so protective toward her adoptive daughter.
- It is likely that after her son's birth, Susan remained sterile, since after that tragedy, she and her husband opted for adoption.
- Susan's maiden lastname is unknown.